SYNTHESIS is an international journal and double-blind peer-reviewed biannually journal published by SYNTIFIC Publisher cooperated with ICMJE. SYNTHESIS is open access journal to communicate high-quality research articles, systematic review, literature review, case studies, case series, case reports, and articles of community services. SYNTHESIS only receive original paper and has never been published in a previous journal or considered to be published in another journal (proven by: 1) Ethic of publication with ICMJE form for disclosure of potential conflicts of interest, 2) Tolerance of plagiarism less than 20%).